Pinnacle Hip MDL

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Mental Health

Research Links Metal-on-Metal Hp Replacement Systems to Mental Health Issues

The authors of a first-of-its-kind study encouraged doctors treating patients who have had hip replacement surgery involving a metal-on-metal

According to the research, the presence of these heavy metals could lead to cognitive issues such as depression and dementia like symptoms. The research, published by the National Center for Biotechnology Information and under the umbrella of the National Institutes of Health chronicles patients in the United Kingdom who went through the surgery and received a metal-on-metal hip replacement system, such as DePuy Orthopaedic’s Pinnacle system, which has since been recalled. To date, the maker of the Pinnacle system, has been found liable for hundreds of millions of dollars in damages to patients who suffered issues after their implantation. The Pinnacle system was found to have both design and production flaws, leading to the failure. DePuy Orthopaedics is a subsidiary of Johnson & Johnson. Metal-on-metal hip replacement systems use a metal ball and joint, rather than a plastic or ceramic joint. However, these systems have failed at a higher than normal rate, requiring revision surgery or surgeries and causing other problems, such as irritation at the implantation site. Another problem has been the heavy metal shavings that can lead to bleeding at the implant site or leech into the patient’s bloodstream. This condition is called “metallosis.” Metal-on-metal hip replacement systems use cobalt and chromium, both of which can cause various health issues. The NIH study found that the cobalt and chromium shavings were having mental health effects on the patients: “We present the first case series suggestive of clinically significant depressed mood and neurocognitive impairment following MoM hip failure with concomitant chromium and cobalt toxicity.” The study recognized that some of the mental health issues could have stemmed from worry about the hip replacement system failure and potential ramifications. However, the researchers determined that there was more at play: “Neurocognitive abnormalities however might be mediated by either static brain damage caused by chromium and cobalt toxicity or could represent a dynamic process, that is an early onset dementia triggered by metallosis. If the latter is the case it might have major, as yet unrecognised, implications for public health.” The researchers concluded that metal-on-metal hip replacement systems should be removed even if they have not yet failed: “Other than revision surgery there is no effective adsorption or chelation therapy for chromium and cobalt, and if such therapies could be safely developed, it may avoid the need for further surgery. In the meantime, to preserve neurocognitive function implant removal conceivably should be as soon as possible after toxicity is detected.” Though the researchers noted the potential effect on product liability cases ongoing and in the future, they commented that patient health is more important than commercial concerns: “There are additionally potential public health implications for the care needed by many thousands of patients who have potentially suffered MoM related cobalt and chrome toxicity, should progressive cognitive decline be found in this group and the associated requirements for dementia care. This has some relevance to product liability litigation worldwide. However we believe that any commercial factors should be set aside in the interest of public safety and the bioethical principle of social justice.” The study focused on patients in the United Kingdom who underwent hip replacement systems with a metal-on-metal ball and joint. The researchers narrowed down their patient list to 10 patients whose systems had failed. They found that before revision surgery, nine of the 10 were suffering from toxic levels of chromium and cobalt in their blood. All nine of those patients met clinical criteria for depression at a “moderately severe” level. Seven of the nine exhibited short-term memory loss. Other cognitive problems seen in the patients included disorientation, problems with tests of concentration and word finding difficulties. --authored by Rick Fahr.



Pinnacle Hip - Fifth Circuit Legal Rulings
Lexology
The forceful reiteration of conservative principles of Erie predictions of state law leave us hopeful that the Pinnacle Hip MDL will see some Fifth Circuit-mandated clean up – or, if not, perhaps the appellate court's not-so-veiled Parthian, parting ...


DrugWatch.com

DePuy Pinnacle Hip MDL Trial Gets Underway in Texas
DrugWatch.com
Johnson & Johnson's attempt to convince doctors that its DePuy Pinnacle artificial hips were safe was a result of “marketing run amok.” Instead of fixing design flaws, the pharmaceutical company's medical device maker assured doctors that the hips ...

and more »

5newsonline.com

Recently Released Sex Offender Is Relocating To Fayetteville
5newsonline.com
WASHINGTON COUNTY (KFSM) — A Level 2 sex offender has been released from custody and will be living at the 14200 block of Dogwood Drive in Fayetteville, Arkansas. Joshua Glen Box was convicted of Possession of Child Pornography on August 3, ...


4029tv

Fayetteville man dies in motorcycle accident
4029tv
A 21-year-old has died after crashing his motorcycle. Police say a car was travelling southbound on W Old Farmington Rd. when it approached the Hwy 62 intersection. That's when the car made a left hand turn, turning into the direct path of 21-year-old ...

and more »


Metal poisoning

Pinnacle Hip MDL:Orthopaedic Group Urges Caution for Metal-on-Metal Hip Replacement System Recipients

Pinnacle Hip MDL:Metal-on-Metal Hip Replacement System Failures can Lead to Severe Health Issues Heavy metal poisoning isn’t something a hip replacement patient may consider a real danger, but it is.
DePuy Damages

DePuy Pinnacle Metal-on-Metal Hip Replacement System Found at Fault in Texas Lawsuit

Johnson & Johnson has been ordered to pay nearly a quarter-billion dollars to six plaintiffs in a so-called “bellwether” lawsuit. The case, in a Texas federal court, pitted the defendants against the company
Health Risk

MOM Link to Dementia/Heart Disease

Metal-on-metal hip replacement systems have been known to cause various problems — including painful revision surgeries and the accompanying physical rehabilitation — but researchers have recently discovered a potentially new and devastating side effects — a link between metal-on-metal hip replacement systems and dementia and heart disease.

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